Stay:
Times Square Suites
http://www.timessquaresuites.com/
These are clean, large apartments right in the thick of things. They are also cheaper than a hotel and come with a full kitchen, a balcony, windows that open, total quiet and privacy, more tvs than you will know what to do with, and a washer/dryer in case you need one.

Eat:
Bin 941 – very festive and tiny tapas restaurant
http://www.bin941.com
One of my favorite restaurants ever, anywhere. They have two locations and we've only been to the Davie St. one. Kobe beef, mussels, asparagus and Navajo flat bread are a-m-a-z-i-n-g. No reservations, and always a long wait. Put your name down and grab a drink someplace nearby while you wait.

Alibi Room – Fusion-y food, and good for dancing.
http://www.alibi.ca/
This is the original Alibi. The other one is one of the coolest places in Seattle.

Tsunami Sushi – melt in your mouth sushi
http://www.vancouverplus.ca/portal/profile.do?profileID=383176
Perfect for lunch, and right on Robson Street.

Sun Sui Wah – Fab Chinese, perfect for dim sum
http://www.sunsuiwah.com/e-about-1.html
Outside Vancouver, on your way back home. And better than anything you've ever had.

Crime Lab – general fusion-y
http://www.greatestescapes.com/index.php?revid=72&issue=2000-10-01
The food is pretty good, but the drinks are amazing. The restaurant stands where a forensics lab used to be, so all the drinks are named after strange diseases and ways in which people die.

Yale Town Brewery – bar food
http://www.nwbrewpage.com/bcbpubs/Yaletown.html
Good for a break, a drink and people watching.

Cupcakes – Cupcake shop
On Denman, great for after-park activities
http://www.cupcakesonline.com/

I am omitting an Indian place that many of my friends who go to Vancouver love. And a Korean place Jane and Jas love that is off of Robson (I can’t remember what it is)

Activities:
•    Bike around Stanley Park
•    Eat a cupcake at Cupcakes when you're done with your bike ride.
•    Walk around the Gastown District, the oldest part of Vancouver.
•    Eat your way through Granville Island – like Pike Place Market but a zillion times better and cleaner.
•    Shop on Robson Street. Everything you could ever want in a shopping district and all at Canadian prices!
•    Visit the Vancouver Library – an amazing indoor/outdoor space modeled after the Roman Coliseum.
•    Shop for overpriced goods at sleek boutiques in Yaletown.
 
Sample weekend, since I know you're curious ;)

Friday night
•    Check in to Times Square Suites
•    Go across the street to Safeway and grab some snacks for Saturday breakfast
•    Take a nice stroll to Bin 941
•    Get a drink some place nearby while you're waiting for your table

Saturday (this is probably impossible to do in one day)
•    Get up as early as possible
•    Nibble on the breakfast treats you purchased at Safeway
•    Go across the street and rent a bike
•    Ride around (the perimeter of) Stanley Park
•    Eat a cupcake at Cupcakes when you're done
•    Book over to Gas Town for a quick stroll
•    Walk over to Yaletown and do a little shopping (most of the shops are closed on Sunday)
•    Grab a drink and a rest at Yaletown brewer
•    Go back to homebase for a quick break
•    Go to the top of the Empire Land Mark hotel for a drink at sunset
•    Cab over to this Indian restaurant I won’t mention by name.

Sunday
•    Go directly to Grainville island and eat your way through all the stalls
•    Assuming you’re driving, say bye bye to Vancouver and have a mid-afternoon Dim Sum at Sun Sui Wah (they stop serving at 3pm,